In all cases hepatocytes represented the main cellular population (≥ 80% of overall cellularity).
(A) A communication-based gene circuit that confers the auto-regulation of cellular population density.
Note that besides the intracellular level, several studies in SB also address the cellular population level.
Due to their spatial features their main applications are related to molecular dynamics and cellular population dynamics.
Using a custom-tailored microfluidic device, the authors were, for the first time, able to establish and tune synchronized oscillations of an entire cellular population (thousands of cells).
Since it has been long recognized that cancer cells represent distinct cell lineages separable from the normative genomic structure [2], they are a unique self-referential cellular population.
In both photoprotected and photoexposed skin the cellular population is concentrated in the epidermis whilst in the dermis, fibroblasts are sparsely distributed.
A positive feedback regulatory architecture arises here from the self-activation of LuxI synthesis to facilitate the synchronization of the cellular population.
We highlight examples of natural biological responses spanning the cellular, population and microbial community levels that show promise in synthetic biology contexts.
In our model, Intracellular signaling pathways were represented by ordinary differential equations, while the intercellular communications and cellular population dynamics were modeled by stochastic differential equations.
Recent mathematical studies show how the size of the cellular population in a local patch of tissue influences the spread of cancer-promoting mutations.
