Sentence examples for cellular polymerase from inspiring English sources

The herpes DNA polymerase, which appears to provide partial helper function under some conditions [46], [48], has also been shown to be completely dispensable for rAAV production [49], suggesting that a cellular polymerase may be necessary in the presence of Herpes coinfection.

Whether the viral polymerase or a cellular polymerase elongates the 3′ end of the plus strand remains unclear.

Following HBV infection, RC DNA translocates into nucleus, where it is repaired by cellular polymerase to form covalently closed circular DNA (cccDNA) that is subsequently transcribed into pre-core RNA, pgRNA, surface mRNA and X mRNA [ 4].

AAV DNA replication requires the ITR, cellular polymerases, and helper virus-derived factors.

Presently, potential nRTIs are evaluated to select candidates with a much greater potency against target pathogen polymerase enzymes than against normal cellular polymerases.

The effect is lost by deletion (Del33) (aminoacids 1709 1913 without residues 1737 1836) of the interaction region with SV40 large T antigen, a viral polymerase, suggesting that the mechanism might be controlling the specificity of the interaction of p300 with cellular polymerases and their association or integration in transcriptional complexes.

Since retroviruses may be more sensitive to dNTP pool alterations than cellular polymerases, we hypothesized that gemcitabine would be an alternative to hydroxyurea that could be translated to clinical use for the treatment of retroviral infections when used in combination with current anti-retroviral therapies.

The major off target effects are due to interactions with other cellular polymerases, in particular mitochondrial DNA polymerase γ (encoded by the nuclear POLG gene) [ 96].

As the viral-like RNA cannot be transcribed into mRNA by cellular polymerases, mCherry protein is only produced in cells expressing all five viral components.

Such drugs would have to be screened, as has been done in the past, for off target effects on other cellular polymerases.

However, PVs do not encode for any element of the genome replication machinery and rely instead in cellular polymerases for replication (Park et al. 1994).