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The most important cellular player in the production of the extracellular matrix is the myofibroblast (MF).
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For 40 years myofibroblasts have been recognized to be the key cellular players in fibrosis.
The whole three-dimensional (3D) structure of the cochlea is needed for auditory perception and transduction, but the sensory hair cells are the key cellular players in these events.
Particularly, new studies which closer delineate the main cellular players in AD, their histamine-responsiveness, and findings on the most recently discovered HR, the H4R, suggest that novel targeting strategies incorporating the H4R could be effective in targeting not only pruritus but also inflammation in this abundant pediatric skin disease.
Further investigation on the role of new cellular players in resolution.
Two major cellular players in these processes are macrophages and fibroblasts [ 1- 4].
One of the central cellular players in this system is the endothelial cell (EC).
Indeed, we demonstrated that tenascin-C is expressed at both mRNA and protein level in LPS-activated BMDMs, the major cellular players in sepsis.
Besides possessing regenerative potential, Deiters' cells are the key cellular players in the pathophysiologically important wound healing in the auditory sensory epithelium [ 34].
As a result of this ability, these cells are considered to be the main cellular players in the processes of bone regeneration and healing.
The central cellular players in GCA are vessel-embedded DCs that sense danger signals and T cells that mount an adaptive immune response at the tissue site [ 17].
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