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Osteoinductive materials provide a biological stimulus for induction, recruitment, stimulation and differentiation of primitive, undifferentiated and pluripotent stromal cells into osteoblast or preosteoblasts, which are the initial cellular phase of a bone-forming lineage.
Some studies have proposed DIP as the cellular phase of UIP because of some similarities in histopathological features, but this idea was not sustained by Carrington et al. because of the poor prognosis for UIP and the absence of response to corticosteroid therapy in comparison with DIP [52].
In the same experiment, we asked if restoring macrophage numbers during the cellular phase of the granuloma could delay its necrosis.
However, these proof-of-concept experiments could only assess the effect of macrophage replenishment during the early cellular phase of the granuloma.
Our results so far suggested that the first cellular phase of granuloma growth occurs when macrophage supply is not limiting and is therefore driven mainly by macrophage demand.
Taken together, our findings suggested that the first cellular phase of bacterial expansion in the granuloma proceeds normally in the mutant, but the second phase of granuloma necrosis and extracellular bacterial growth occurs earlier.
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James E. Darnell, Laboratory of Molecular Cell Biology, The Rockefeller University, New York 10021, USA (nominated by W. Ford Doolittle) I think speculation on the origin of eukaryotic cells that does not go back to the pre-cellular phase of evolution unlikely to unlock any secrets and at worst to be vacuous.
However, the quantity of macrophages demanded during the cellular phase should also influence the time of onset of the necrotic phase of the granuloma by influencing the rate of macrophage depletion.
Fibrinogen participates in both the cellular phase and the fluid phase of coagulation [ 1].
Fibrinogen is a soluble plasma protein, which participates in both the cellular phase and the fluid phase of coagulation [ 1].
The cell cycle can be described by four successive cellular phases: a phase of cell growth to prepare for DNA replication (G1), a phase of DNA synthesis and replication (S), and a phase of cell growth and active synthesis of factors (G2) required for mitosis (M) (Malumbres and Barbacid, 2009).
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