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The method should be generally applicable for uncovering the cellular pathways triggered by other extracellular stimuli.
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However, further study are necessary to elucidate the role played by FAK and other kinases in the activation of specific cellular biochemical pathways triggered by NPs interaction with cellular systems.
The vascular endothelium plays a central role in the inflammatory process and cytokine production, and various cellular signaling pathways trigger this response.
Perhaps the most critical is to elucidate the direct cellular targets of LCA, responsible for the variety of antiaging pathways triggered by this compound.
The molecular pathways triggered in these cells induce marked changes in gene expression causing modulation of their cellular phenotypes resulting in proliferation, differentiation or migration.
The molecular cell death pathways triggered by the critical DNA lesions are not predictable and appear to be dependent on the cellular background.
Not much is known about the genes and cellular pathways that trigger GNRH release.
This may suggest a higher affinity for Mal binding and would perhaps explain why TRAM is not subjected to such high levels of cellular regulation and also why Mal/MyD88 pathways trigger early NF-κB expression, but TRAM/TRIF signalling results in late NF-κB expression.
Therefore, we tried to investigate the toxicity pathway triggered by these polymers through a high-content cellular imaging technique.
Presence of widely occurring sensory domain in Ser/Thr kinases of Nostoc further emphasises on its role in the perception of some critical signals that are likely to trigger cellular pathways synergistically.
There are two main apoptotic pathways: the extrinsic pathway, triggered by cell surface receptor engagement and the intrinsic pathway triggered in response to cellular stress signals and dependent on mitochondria [ 24].
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CEO of Professional Science Editing for Scientists @ prosciediting.com