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Further analysis of the molecular and cellular pathways regulated by these genes should help to provide some insight into the neuroadaptive potentials of the brain when repeatedly exposed to drugs of abuse.
The number of cellular pathways regulated by progesterone reflects the complexity of its physiological role.
For example, cellular pathways regulated by TGF-beta and integrins seem to be connected [ 24].
Figure 5 illustrates the cellular pathways regulated by the differentially expressed proteins in spermatozoa [ 18].
A better understanding of the network of genes and cellular pathways regulated by these miRNAs will undoubtedly enable us to understand breast cancer pathogenesis and therapy.
To elucidate cellular pathways regulated by HMGA1 early in tumorigenesis, Ingenuity Pathway Analysis (IPA, Ingenuity® Systems, http://www.ingenuity.com) of selected genes from our microarray data was used.
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Dimerization-driven activation of the intracellular kinase domains of the epidermal growth factor receptor (EGFR) upon extracellular ligand binding is crucial to cellular pathways regulating proliferation, migration, and differentiation.
Functional analysis demonstrated that several cellular pathways regulating cell attachment were affected in the tumor tissue.
The PI3K/AKT signaling pathway is one of the most important cellular pathways regulating HCC progression and affects cell proliferation, motility, and survival [ 12, 13].
In the last years, significant progress has been made in the understanding of the cellular pathways regulating cell death and in therapeutic strategies to promote tumor cell death.
These experiments demonstrated that iron given as FAC readily accumulates in T51B cells in a uniform fashion with expected effects on cellular pathways regulating iron metabolism.
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