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Understanding cellular pathways is crucial in cancer research, and these pathways need to be considered in the context of the progression of cancer at various stages.
Concomitant targeting of different cellular pathways is considered as a promising strategy in tumor treatment.
Understanding the nature of these cellular pathways is of central importance in cancer biology.
A valuable tool to assign a set of genes to cellular pathways is the KEGG pathway database.
This limitation to ubiquitous cellular pathways is a necessity since expression profiles themselves are already large datasets.
Obtaining a predictive understanding of information propagation and decision-making in cellular pathways is one of the paramount goals of systems biology.
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Cellular pathways are established and maintained by stochastic interactions of highly mobile molecules.
To assess some of the direct effects on proximal tubular cells, changes in gene expression of selected cellular pathways were determined after exposure to angiotensin II.
As a number of prominent cellular pathways are critical to the survival of both tumor cells and heart cells, it comes as little surprise that therapies targeting those pathways have consequences in both tissues.
In line with this, identification of PPIs at genome-wide scale is highly valuable to understand how different cellular pathways are interconnected, and it eventually facilitates designing effective drugs against certain PPIs.
Benign cellular pathways are complex, malignant ones more so [9].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com