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Spurred by the discovery of a cellular pathway that helps switch cell growth on and off, research in the Sabatini lab has linked growth to a cell's ability to sense nutrients in its environment.
While studying the impact of the 2010 Deepwater Horizon oil spill on tuna, a research team led by Barbara Block, a professor of marine sciences, discovered that crude oil interrupts a cellular pathway that allows fish heart cells to beat effectively.
Autophagy is a conserved cellular pathway that serves to degrade bulk cytoplasmic material ([10], [11]).
Autophagy is a well-recognized ancient conserved cellular pathway that removes macromolecules, recycles and degrades unwanted cytoplasmic components [30].
On the other hand it is well possible that TA targets a yeast cellular pathway that is either absent in mammals or that is too divergent to be efficiently targeted by this drug.
Even though the direct expression of Aβ constructs containing a preproenkephalin secretory signal in Drosophila neurons may not mirror the normal conditions of Aβ generation from full-length of APP, our observations suggest a mechanism for differential neurotoxicity of Aβ1 42 and Aβ1 40 as well as a cellular pathway that is responsible for Aβ1 42-induced neuronAβ1 42-induced
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Other susceptibility genes come into play as do complicated cellular pathways that may either help promote or suppress immune responses.
These studies uncovered the existence of several previously unappreciated alterations in key cellular pathways that may also influence treatment outcome.
A deep quantitative proteomic study of the Ciprofloxacin resistant mutants uncovered the cellular pathways that supported such resistances.
They could form the basis for research into the cellular pathways that are important to the ageing process.
We describe a novel mechanism for impacting gene expression directly at the protein level and demonstrate that the absence of this mechanism leads to misregulation of cellular pathways that are essential to neuron development, function, and survival.
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CEO of Professional Science Editing for Scientists @ prosciediting.com