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Lung cancer is the leading global cause of cancer death in both men and women [44], but its molecular and cellular pathogenesis is not well understood [45].
However, since both secretion systems are required for productive L. pneumophila infection, it is equally plausible that the progression of cellular pathogenesis is required to set up the proper environment for rRNA cleavage, independent of whether or not the cleavage is carried out by a bacterial enzyme.
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In summary, signs of cellular pathogenesis were consistent with those observed during characterization of this disease model and were unchanged by long-term treatment with testosterone.
Transverse myelitis (TM) is a rare inflammatory disorder of the spinal cord affecting approximately 350 children and adults annually in the UK. 1 2 Histologically, TM is characterised by spinal cord immune cellular infiltration, and pathogenesis is mediated by a variety of immunological mechanisms.
Although the role of cellular invasion in colonisation and pathogenesis is unclear, previous work has shown that S. aureus can persist within keratinocytes for extended periods and it is possible that invasion provides shelter from the host antimicrobial arsenal.
Understanding cellular and molecular mechanisms of tumor pathogenesis is critically important for the development of new approaches to cancer treatment.
Our results are generally consistent with the MST, where the timing of pathogenesis is controlled by host cellular metabolic rate.
Despite recent progress in the delineation of cellular pathways aberrantly modulated in NSCLC, our understanding of the molecular changes occurring early in NSCLC pathogenesis is still lacking.
Meningococcal pathogenesis is a rare event that relies on the ability of the bacteria to break host defences such as cellular epithelial or endothelial barriers [5], [6].
Pathogenesis is poorly understood.
Many cellular studies of FRDA pathogenesis were, and are still, conducted using patient-specific immortalized lymphoblasts, primary fibroblasts or peripheral lymphocytes.
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