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We found reduced cellular oxygen consumption after restoring tissue oxygenation to baseline levels with fluid resuscitation.
However, improved cellular oxygen supply implies an improvement in microvascular perfusion.
Thus, regular DO parameter detected by DO probe loses the role to represent cellular oxygen metabolism.
In addition, cellular oxygen dynamics are critical in maintaining intestinal homeostasis.
The latter may then react with cellular oxygen to form O2− and genotoxic hydrogen peroxide (H2O2).
The cellular oxygen demand also fluctuates depending on tissue type and growth phase.
The intestines have a dynamic and rapid fluctuation in cellular oxygen tension, which is dysregulated in IBD.
The increase in mitochondrial internalization is correlated with increased cellular ATP content and cellular oxygen consumption [19, 34].
HIF-α subunits are regulated through a well-characterized hydroxylation-induced proteasome-mediated degradation during normal cellular oxygen tension.
The amperometric devices are built on the fiber optic surface and are designed to measure cellular oxygen consumption.
Hypoxic stress, that occurs when cellular oxygen demand is higher than its supply, is a commonplace in tissues faced with infection and inflammation [7, 8].
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