Given that aptamers are very good at binding membrane proteins, the door is now open for targeting proteins that reside within intracellular vesicles so as to engage endosomal biology and modulate cellular outcomes at the endosomal level.
He and co-workers' study suggests that molecular function, rather than genotype function — in this case, the specific role of BRCA1 in resection, rather than its overall role in HR repair or in fork protection — dictates the cellular outcomes.
Studies with NF-κB inhibitors can map functional details of the NF-κB pathway and the influence of radiation-induced NF-κB activation on various cellular outcomes such as survival or cell cycle arrest.
A very broad range of physical and biological properties have been engineered into HA PEG hydrogels that may differentially affect cellular "outcomes" of survival, synthesis and metabolism.
In the context of DNA damage, p53 is thought to be a decision-making transcription factor that selectively activates genes as part of specific gene expression programmes to determine cellular outcomes.
As a result of a close collaboration between biologists, engineers, and physicists over the past decade, the types of mechanical parameters which influence stem cells, along with the corresponding cellular outcomes, have started to emerge.
While some PTMs directly modulate chromatin architecture via charge effects, others rely on the action of reader or effector proteins that can recognize and bind the modification to fulfill distinct cellular outcomes.
These cellular outcomes proceed through natural cellular engineering.
Our data suggest that the regulation of NMDA-r function by nitroxyl anion is distinctly different from NO and may result in different cellular outcomes compared with NO.
The Payne Lab studies the interaction of materials with cells with the goal of using material properties to control cellular outcomes.
Fleischer, CC, and Payne, CK. "Nanoparticle-cell interactions: Molecular structure of the protein corona and cellular outcomes". Accounts of Chemical Research 47 (2014): 2651-2659.
