Sentence examples for cellular niche from inspiring English sources

Muse cells exist in a quiescent state under normal physiological circumstances within the cellular niche prior to cellular stress disruption [24, 26].

From that base, inter-domain and cell-cell communications enable genetic and cellular variations through self-referential natural informational engineering and cellular niche construction.

Using a combinatorial materials approach we develop a synthetic, chemically defined cellular niche for the support of functional cardiomyocytes derived from human embryonic stem cells (hESC-CMs) in a serum-free fully defined culture system.

In the current study, we use bone marrow (BM)- and adipose (AD -derived stromAD -derived prepare BM-ECM and AD-ECM, which are decellularized after stromalis by the cells, to mimic the cellular niche for each of these tissues.

They are important mediators of intercellular communication and regulators of the cellular niche, and their altered characteristics in many diseases, such as cancer, suggest them to be important both for diagnostic and therapeutic purposes, prompting the idea of using exosomes as drug delivery vehicles, especially for gene therapy.

These cells are diploid and clonogenic and undergo sustained symmetrical self-renewal divisions in response to FGF2 and EGF independent from any specific cellular niche.

This approach enables further dissection of key cellular and niche components involved in thymic epithelial stem cell maintenance and T cell production.

Placed in a self-referential frame at the cellular level, niche construction becomes a directing process towards common cellular aims and cooperative purposes operating at that scope and scale and can proceed without any external direction.

Reprogramming might be achieved by changing the cellular microenvironment (niche), in which the cells grow, to provide signals that might activate appropriate metabolic pathways.

Barker also presented data demonstrating that clonal outgrowths can be generated and passaged in Matrigel cultures in the absence of a cellular stromal niche, and that cells from these structures have the potential to contribute to the colonic epithelium when introduced into suitable recipient mice.

Each of these is used to advantage through the cellular mechanisms of niche construction and stigmergy common to all cellular networks.