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Therefore, studies on the biological effects of imatinib on different cellular models are very important.
In this article, we describe how investigations of these and other candidate genes, in humans, animals and cellular models, are unravelling the connections between genes and cognition.
Despite significant progresses in this field, cellular models are not yet able to provide a source of myocardial cells that will efficiently integrate and substitute damaged myocardial tissue.
These hepatic cellular models are apparently suitable to experimentally investigate the impact of fat overaccumulation in the liver excluding other factors that could influence hepatocyte behaviour.
Although great advances in hBAT biology have been achieved in the past decade, more cellular models are needed to acquire a better understanding of adipose-specific processes and molecular mechanisms.
This should be taken into account when cellular models are used for molecular and biochemical studies in McArdle's disease.
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Animal and cellular models were used to study Erk5 expression and function in breast cancer.
Therefore, the use of appropriate cellular models is advantageous.
One reason for this state of affairs is the fact that simulating cellular models is computationally expensive, when compared to the data processing tasks.
Since the biological activity of ALK mutations extends beyond the specific type of fusion, both NPM-ALK and EML4-ALK-positive cellular models were used.
The increased accumulation of LC3-II obtained for all those cellular models was also evident in sPD patient peripheral blood lymphocytes (Supplementary Material, Fig. S3A and B).
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