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The additional stratification tools, i.e. cognitive and imaging-related phenotypes and environmental stress factors, might help to identify representatives of (sub groups with verified WM pathophysiology and subsequently to investigate their underlying mechanisms and their impact on cognition in SCZ, e.g. with hiPSC-based cellular modelling (Fig. 2a).
This review aims to (i) revisit dysfunctions of OPCs/OLs in SCZ, including and beyond myelination, and (ii) discuss strategies for patient selection towards stem-cell generation and cellular modelling as a pre-requisite to target OPC/OL deficits with pharmacological approaches.
Trained in molecular biophysics, Wade heads the Molecular and Cellular Modelling group.
Finally, quantitative FRAP and cellular modelling were used to determine the duration of viral genome replication.
The field of molecular and cellular modelling is still in its infancy, but manuscripts in these areas would be equally welcome in the section as they are important and growing areas of research.
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Animal and cellular models of chronic pain.
C2C12 myoblasts were used as cellular models.
(a) Strategy for generating mESC models, or mESC-derived cellular models, and mouse models carrying a chromosomal translocation.
We have investigated the fate of amyloid as a model antigen in a cellular model of vaccination.
Here, we used this TERRA knockout cellular model to address the role of TERRAs in the establishment of telomeric chromatin.
Cantariño, N. et al. A cellular model reflecting the phenotypic heterogeneity of mutant HRAS driven squamous cell carcinoma.
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