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Interestingly, APP overexpression leads to progressive defects in our behavioral paradigm (Fig. 1E, F), and paralleled some of the abnormalities observed in enarev mutants (Figs. 1, 6 and 7), suggesting that similar cellular mechanisms could be affected in our model of neurodegeneration.
Many cellular mechanisms could enhance central gain, but one likely candidate is reduced inhibition (disinhibition).
Moreover, it may place a constraint on what sorts of cellular mechanisms could have emerged in evolution before we reached our homeothermic state.
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Characterization of this cellular mechanism could have clinical implications by supporting the development of new diagnoses or treatments for these allergic diseases.
Characterization of this cellular mechanism could have clinical implications by supporting development of new diagnosis or treatments for the organ-specific autoimmune diseases such as Sjögren's syndrome and clarifying how the local immune system regulates autoimmunity.
However, the cellular mechanism could not be resolved.
Some data in humans have shown that about 30 50% of genes coding for proteins are controlled by miRNAs [ 26]; therefore, any signalling pathway or cellular mechanism could potentially be governed by them.
This investigation was designed to evaluate cellular mechanisms that could contribute to slowed cytosolic Ca2+ removal and myocyte relaxation in glucose-induced cardiomyopathy.
In the next experiments we examined cellular mechanisms that could potentially mediate learning in the absence of NMDAR activation.
Thus, the isofuranonaphthoquinone showed cytotoxicity, works through inhibition of some cellular mechanisms, and could present a potential source of lead compounds for anticancer drug development.
In addition, regulation of growth control and apoptosis can also be carried out through p53-independent cellular mechanisms which could circumvent developmental defects in the majority of p53-deficient mice.
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