Considering the importance of MRI in diagnosing diseases, this paper presents an overview of recent scientific achievements in the development of new synthetic SPMNP probes whereby the sensitive and target-specific observation of biological events at the molecular and cellular levels is feasible.
An understanding of how RTK stimuli act at cellular levels is needed, however, to evaluate their mechanism of therapeutic action.
Understanding how therapeutic reagents act at cellular levels is needed to accelerate the progress of promising treatments towards the clinic.
Finally, high spatial resolution at cellular levels is required to examine differences in metabolic properties between the cancer foci and the surrounding host tissues.
Future studies will merge histopathology and gene expression analysis with molecular monitoring to identify whether pathology at the molecular and cellular levels is associated with high-load carrier states of microparasites.
Consequently, a growth- or tumor-promoting role is not unusual, but our understanding of it at the molecular and cellular levels is largely based on inferences drawn from subcellular localization and evaluation of the affect of protein levels on proliferation and apoptosis.
