Since ITF2357 showed anti-fibrotic effects at the cellular level, we wanted to examine its functionality in an in vivo rabbit corneal fibrosis model established previously6.
To further verify the chromosomal translocation events at the cellular level, we adapted the chromosome painting technology to mark chromosome 5 with red fluorescence and chromosome 7 with green22.
To reconcile the gap between the reported models and molecular pathways at the cellular level, we have related the single-cell-level in-vitro nanotherapeutics incorporation and its apoptotic action as well as drug efficacy in in-vivo tumor model.
To determine the anti-fibrotic effects of ITF2357 at the cellular level, we used the classical in vitro model of corneal fibrosis where pHCSFs were stimulated with 1 ng/ml TGFβ.
In order to study the effects of forces at the cellular level, we utilized two hierarchical, in vitro systems to mimic traumatic injury to rat cortical neurons: a high velocity stretcher and a magnetic tweezer system.
So from the cellular level we learn why, for example, cancer risks are based not so much on genetic disposition but on where we live and what we eat, drink and inhale; why some rare cancers are, in fact, contagious; and why aging is "a correlate, not a cause, of most cancers".
To help better understand this relationship of bladder function to growth at the cellular level we used a novel method of applying cyclic hydrodynamic pressure that simulates the bladder cycle to cell cultures.
At the protein level, we analyzed the structure and integrity of mutant molecules, and at the cellular level, we specifically studied the effects of the presence of the R992C collagen II on the biological processes taking place in host cells.
To verify the protective effect of HQH on the kidney at the cellular level, we performed a CCK 8 experiment in cisplatin-treated renal tubular epithelial cells after HQH pretreatment, which showed that HQH pretreatment increased the viability of TECs in a dose-dependent manner from 0 mg/mL to 12 mg/mL (Fig. 5a).
At the cellular level, we compared remapping between different neuron types of layer IV.
For the in situ apoptosis detection at the cellular level, we used the ApopTag red in situ apoptosis detection kit (Chemicon International, Temecula, CA, USA) for the terminal deoxynucleotide transferase dUTP nick end labeling (TUNEL) assay.
