Our bioengineered skin-based system represents a robust platform to reliably assess the molecular and cellular mechanisms underlying the complex interdependence between epidermal cells and the immune system.
Moreover, our study showed a strong correlation of NT occurrence and cellular cholesterol contents, demonstrating an interdependence of NT mediated cell communication, cytokine action and cholesterol homeostasis.
The interaction of adhesion molecules and sheddases in the dynamic microenvironment of the cellular surfaces implicates a strong interdependence of these molecules.
The surfactant system, alveolar interdependence, collateral ventilation, extra-cellular matrix, and mechanical properties of the chest wall work together to avoid alveolar collapse.
This also involves regulation of the cellular lipid repertoire, further highlighting the high degree of interdependence of these processes (Andreyev et al., 2010; Dennis et al., 2010; Maurya et al., 2013).
The concept of osteoimmunology emerged more than a decade ago and is based on rapidly growing insight into the functional interdependence between the immune system and bone at the anatomical, vascular, cellular, and molecular levels [ 1].
Although their interdependence is not clearly understood, autophagy and senescence are integral processes of the cellular response to stress agents [ 96].
Therefore, it has to be considered that almost every cellular pathway may be influenced by chromatin-modifying enzymes, and a complex, yet still elusive interdependence between chromatin dynamics and cellular regulation pathways exists.
Such exposure of the interdependence among those aspects introduces the tissue level into the general conversation on tumor biology at cellular & molecular levels.
