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Growing evidences suggest that the anatomy of secondary lymphoid organs (SLOs) fosters the cellular interactions required to initiate naive adaptive immune responses.
However, application of β-defensin 3 alone did not result in an increase in wound closure (data not shown) implying that topical application of a single defensin does not sustain the cellular interactions required for increased chemo attraction, cellular recruitment and wound closure.
Regulated assembly, rearrangement and disassembly of F-actin are critical in a wide variety of cellular processes, including cell morphology, cell motility and cellular interactions required for tissue formation and integrity (reviewed by Geiger and Bershadsky, 2001; Revenu et al, 2004; Chhabra and Higgs, 2007).
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In general, B cell responses against pathogen derived-antigens are generated through complex cellular interactions requiring the coordination of innate and adaptive immune mechanisms.
Distinct cellular interactions are required to support further the long-term growth of rheumatoid synovium.
Multiple signals and cellular interactions are required for the maturation, expansion, and maintenance of thymic epithelial compartments.
We examined FlpA, a C. jejuni Fn-binding protein composed of three FNIII-like repeats D1, D2 and D3, to identify the interactions required for cellular adherence on pathogen-induced host cell signaling.
The identification of the exact cellular interactions and signals required for the modulation of Notch by the Slit-Robo signalling pathway will be the focus of future studies.
Studies of the cellular and molecular mechanisms underlying these interactions require ex vivo experimental model systems that recapitulate the complexity of human tissue without compromising the differentiation and proliferation potentials of human primary cells.
Despite LTP-based approaches demonstrating considerable promise in cancer treatment, further focussed work on the exact mechanisms of plasma-cellular interaction is required before such a technique could be used therapeutically.
Indeed some protein-protein interactions are too weak and/or transient to be detected in vitro and some of these interactions require specific post-translational modifications of the proteins and/or specific co-factors in the cellular microenvironment.
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