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These observations can be reconciled with a role for EBV in BL pathogenesis by supposing that EBV somehow increases the likelihood of generating cellular genetic changes, most importantly MYC-activating translocations, which drive lymphoma development.
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Pihan, G. A. et al. Centrosome defects can account for cellular and genetic changes that characterize prostate cancer progression.
Over the course of tumorigenesis, these various cellular and genetic changes present as pathologically distinct entities.
However, the cellular and genetic changes that ultimately led to the evolution of multicellularity are not known.
Monitoring cellular and genetic changes following RT is therefore valuable for understanding the effects of RT and for tailoring treatment for LGG patients.
The expression of significant cellular markers, stromal proteins, genetic changes (LOH and comparative genomic hybridisation) or expression profiles could be assessed on biopsy specimens in association with the mammograms so that the risk density relationship can be more fully understood.
Cancer is a complex disease where multiple genetic changes rewire cellular networks during carcinogenesis.
The RA approach has been used in numerous studies to analyze cellular responses to the downstream genetic changes.
While keeping the patients and families foremost in mind, our research seeks to: define and understand genetic causes; clarify the molecular and cellular consequences of genetic change; determine the multisystemic features that are underappreciated but clinically significant consequence of these diseases; develop and improve methods for managing and treating each disease.
We have recently shown that expression of NES-hTERT in primary cells leads to premature growth arrest with accompanying morphological and genetic changes involved in cellular senescence [19].
Cancer cells undergo numerous genetic changes that drive cellular transformation from normal cell progenitors.
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