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A pathway analysis identified that the top molecular and cellular functions represented by our candidate genes were cell death, cell cycle, and cellular growth and proliferation.
Due to the cellular functions represented in IR-transcript profiling, we hypothesize that IR simultaneously triggers three major types of chromatin alterations: DSB-type lesions, non-DSB-type lesions, and increased decondensation-type linked to active transcription (Figure 7).
It is not surprising therefore that photosynthesis was one of the major cellular functions represented in the CTR.
However, the evolution of cellular functions, represented by metabolic pathways and biological processes, has not been systematically characterized.
Despite the apparent differences in the settings of these studies, the cellular functions represented by the top-ranking transcripts were similar.
Structural changes in the G t s should be linked to transitions of cellular functions represented by the G t s over time.
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In part because of their importance in human physiology and disease, these proteins and their cellular functions represent an intense area of study.
For the brain phosphoproteome, the largest cellular function represented was cellular assembly and organization with 102 of the 211 proteins analyzed designated with this function (Table S7).
For the liver phosphoproteome, the largest cellular function represented was gene expression with 61 out of the 119 phosphoproteins analyzed consisting of proteins that regulate transcription (Table S9).
These sophisticated cellular control functions represent new avenues for the therapeutic control of cancer.
The specific molecular and/or cellular functions are represented in Figure S2A.
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