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Because of its influence on vital cellular functions it was considered possible that mutations in the AATF gene might contribute to hereditary disposition to breast cancer.
This interesting in that, although Src is broadly connected to many cellular functions, it is known to be connected to the other targets we verified to be in part essential for U87 mg electrotaxis.
But to truly understand complex cellular functions, it's important to be able to visualize most or all of those workers at once, said Peng Yin, a core faculty member at the Wyss Institute and assistant professor of systems biology at Harvard Medical School (HMS).
Since SIP1 has critical cellular functions, it is obvious that drugs should be highly specific for the IN-SIP1 interface.
Due to such intricate involvement of proteases in a variety of cellular functions, it is not surprising that aberrant changes in regulation of their function is associated with many malignancies [2].
Since the former can be regarded as the basis to realize the latter, playing essential roles in various cellular functions, it is important to investigate spontaneous movement quantitatively at different physiological conditions in relation to a cell's physiological functions.
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Although many techniques have been developed to study phosphorylation and its effects on protein and cellular function, it remains difficult to generate proteins and peptides with defined phosphorylation patterns for detailed in vitro studies or antibody generation.
The work not only revealed a key cellular function, it also illuminated processes involved in disease and aging.
Considering the role of metabolism in the context of the overall cellular function, it is easily understandable why quantifying a complete and accurate metabolomic profile is foreseen to have a major positive impact in cell culture engineering research.
Because proteins play pivotal roles in cellular function and are the minimum unit of cellular function, it is important to clarify the absolute protein expression level in cells, the mechanism of regulation, and the modification of protein function.
It is possible that there are threshold levels of LAMR expression required for each cellular function it regulates and thus with limited expression of exogenous LAMR, only certain functions can be restored.
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