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Each significant network is associated by IPA to three cellular functions, based on the functional annotation of the genes in the network.
The next challenge will be to reconstruct and simulate overall cellular functions based on the extensive reductionist information.
We estimated the essentialities of KEGG pathway maps as the entities of cellular functions, based on comparative genomics and metabolic network analyses.
We show that the reachability profile can help us understand how different disorders that alter the cellular functions based on the signaling patterns of the gene regulatory networks.
However, it is difficult to extract useful information related to cellular functions based on phosphosites alone because it is necessary to understand both the kinase protein and the functional change in its substrate protein caused by phosphorylation.
In addition, the regions were analyzed using Ingenuity Pathway Analysis (IPA; http://www.ingenuity.com/) to identify over-represented molecular and cellular functions based on the Fisher's Exact Test p-value < 0.01.
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Enriched biological processes were categorized after cellular function based on Gene Ontology terms.
Transcriptional response to 1.7 kBq 211At was investigated on the level of cellular function based on established categorization of enriched biological processes (Figure 5).
Biological processes were enriched from significantly regulated transcripts (based on Gene Ontology (GO) terms) and then grouped into categories and subcategories of associated cellular function based on GO ancestor charts (http://geneontology.org).org
Each TUS was assigned a putative cellular function based on the significant database hit with the lowest E-value.
Each unigene was assigned a putative cellular function based on the significant database hit with lowest e-value.
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