The foremost over-represented down-regulated biological functions (P < 0.05) at T4 were related to Molecular and Cellular Functions (Cellular Function and Maintenance, Cell Death and Survival, Cellular Growth and Proliferation).
Two protein-related functions (post-translational modification and protein folding) were specific for the early stage response, while cellular functions (cellular assembly and organization, cell-to-cell signaling and interaction) were specific for the late stage response [Additional file 3].
Genes were classified into three major categories based on their sub-cellular function: cellular component, molecular function, and biological processes.
The Onto-Express module helps to recognize functional profiles (using gene ontology terms) for the categories: biochemical function; biological process; cellular role; cellular component; molecular function, and chromosome location [ 20].
We utilized primary rat hepatocytes to observe the cellular morphology and cellular function of hepatocytes on pristine PDMS, collagen-coated PDMS and GAL-PDMS.
We hypothesized that the augmentation or replacement of mitochondria damaged by ischemia would provide a mechanism to enhance cellular function and cellular rescue following the restoration of blood flow.
So far the plant cells exposed to SWCNTs appear what changes, such as cellular uptake, mitochondrial function, cellular LDH release, apoptosis signaling pathway, reactive oxygen species (ROS) generation and pro-inflammatory cytokine release, etc., are not clarified well.
Similarly the function of "ER stress" is shared across two processes ("Cellular compromise", "Cellular function and maintenance").
For the brain phosphoproteome, the largest cellular function represented was cellular assembly and organization with 102 of the 211 proteins analyzed designated with this function (Table S7).
