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To accelerate the logical drug design procedure, we created the program "NAGARA," a plugin for PyMOL, and applied it to the discovery of small compounds called medical chaperones (MCs) that stabilize the cellular form of a prion protein (PrPC).
The cellular form of the prion protein, PrPC, undergoes extensive proteolysis at the α site (109K↓H110).
Doppel protein (Dpl) is a paralog of the cellular form of the prion protein (PrPC), together sharing common structural and biochemical properties.
The cellular form of the prion (PrPc) is a GPI-anchored membrane-glycoprotein, and is commonly found in many cell-types— predominantly neurons [5], [13], [14].
Prion diseases, generally known as transmissible spongiform encephalopathies or TSE, are fatal neurodegenerative disorders due to the conversion of the cellular form of the prion protein (PrPC) into an abnormal, pathogenic and proteinase-resistant form of the same protein (PrPSc).
The most established molecular model for these diseases proposes that the cellular form of the prion protein (PrPC) is refolded into β-sheet-rich aggregates (PrPSc), which constitute the infectious agent termed prion [3], [4].
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A flow cytometric (FCM) analysis was performed to assess expression of the membrane form of CD44 and membrane and cellular forms of KU80.
The ability to respond to adverse environments effectively along with the ability to reproduce are sine qua non conditions for all sustainable cellular forms of life.
Despite the former, they are still regarded as potential cells that can be used for cellular forms of cancer immunotherapy.
On the contrary, we observed weak colocalization staining intensity within alveolar epithelium surrounding areas of inflammation in cellular forms of NSIP.
The plasma and cellular forms of FN play temporally and spatially distinct and vital roles during the progression of wound healing.
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