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We tested the clinical significance of normal cellular features for predicting pCR using a combination of UVA and MVA logistic regression analyses.
In contrast, the control peptide (GGGAGGGA) shows minimal fluorescence and does not reveal cellular features for either dysplastic or normal mucosa (Fig. 2c-d).
On the other hand, its prominent influence on essential cellular features (for example, metabolism, growth, viability) points to a potential contribution to the pathogenesis of RA (and/or OA) in the case of dysregulated underexpression.
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These changes were the typical cellular features of MK differentiation.
The development of novel tools will be required to investigate how the known molecular mechanisms translate into different cellular features and for the experimental validation of the "logical" connections we postulate in our model.
This is in line with recent findings that tumor cells share an overall gene expression pattern with PSC, which might be caused by the shared molecular and cellular features as, for example, certain genes drive a rapid proliferation rate both in mBL and hPSC.
The observation that alterations in the autophagic lysosomal pathway in response to starvation are common cellular feature of LRRK2 mutations is important for several reasons.
A range of cellular features were measured for all genes, and compared with a positive and negative training set, resulting in a prioritized list of 591 ciliary candidates.
Several unique cellular features are essential for hymenopteran females to produce unfertilized eggs that can develop properly into viable and fertile haploid males.
There are also some cellular features characteristic only for senescent vascular cells (cell-type exclusive senescent phenotype CESP), namely, an increased level of angiotensin II receptor and transdifferentiation of VSMCs to osteoblasts associated with the calcification process (Nakano-Kurimoto et al. 2009) or decrease in NOS activity in ECs (Minamino et al. 2002).
Therefore, we examined the treated parasites for cellular features associated with the apoptosis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com