Cellular diversity is controlled by specific RNAs and proteins, whose expression is influenced by exogenous and endogenous signals.
Cell division orientation during animal development can serve to correctly organize and shape tissues, create cellular diversity or both.
Documenting the extent of cellular diversity is a critical step in defining the functional organization of tissues and organs.
Only cells which display these unique markers were capable of engrafting and generating the cellular diversity evident in human AML [228].
The mammalian brain is considered to be the most complex organ due to its cellular diversity, the variety and scope of its functions and its transcriptional regulation [92].
Indeed, epigenetic regulation of cell fate is part and parcel of normal embryonic development and is a central regulator of cellular diversity.
Due to lung structural complexity with cellular diversity and slow epithelial cell turnover rates, it is still a challenge to isolate and characterize lung stem/progenitor cells for exploring the lung disease processes and endogenous repair mechanisms.
The aim of the Blue Brain Project is to build a replica of a neocortical column, the basic functional unit that makes up the cerebral neocortex while encompassing most of the neocortex's cellular diversity.
Organotypic hippocampal slice cultures (OHSCs) are an attractive in vitro model to examine mechanisms of neuronal injury, because the normal hippocampal architecture, function and cellular diversity are mostly preserved.
First, we describe the cellular diversity within the VTA, including neurons capable of transmitting dopamine, glutamate or GABA as well as neurons capable of multiplexing combinations of these neurotransmitters.
The immune system, with the daunting duty of detecting an astounding number of pathogens, and the nervous system with the equally bewildering task of perceiving and interpreting the external world, are the quintessence of cellular diversity.
