Since diffusion of the FSH receptors, much as diffusion of the cytoplasmic estrogen receptors will be restricted by the cell boundaries, even if cellular diffusion was very fast, we will use D R = 10−7 mm s−1, the diffusion coefficient for unhindered membrane diffusion [ 27- 29, 108], for all other receptors.
The ADC value can theoretically be used to characterise tissues, as the degree of diffusion is correlated to cellular density and extracellular space volume [8, 9].
However, malignant tumours are generally depicted as foci of increased intensity on DW images because water diffusion is restricted in highly cellular tissues as malignant tumours [50, 51].
Studies have shown that regions that appear of high signal on diffusion MRI images are associated with more viable tumour tissue, because water molecule diffusion is more restricted by intact cellular membranes[ 8 ].
While work by Puckett and Barton demonstrated that increasing the lipophilicity of RuIIdppz complexes can promote cellular uptake by passive diffusion, this does not necessarily indicate passive diffusion is the dominant mechanism in all cases.
Water diffusion is restricted within cells and increases following loss of cellular integrity by which ADC DW imaging may be used to monitor cell death.
The restriction of intercellular diffusion is a mandatory prerequisite for effective and regulated transport across cellular barriers.
Diffusion is the valley of death for social innovation.
Water diffusion can occur equally in all directions (isotropic diffusion), for example in cerebrospinal fluid where diffusion is not restricted or in brain tissue where water diffusion is restricted similarly in all directions (e.g., gray matter tissue which has a complex cellular structure).
Moreover, in a number of abscesses diffusion was restricted because of cellular debris and exudates [ 22].
