The ADC depends on a number of factors including the intra- and extra-cellular water diffusion coefficients and transverse relaxation times, the cellular volume fraction, and the tortuosity of the extra-cellular space [35].
The ADC depends on a large number of factors including the intra- and extra-cellular water diffusion coefficients and transverse relaxation times, the cellular volume fraction, and the tortuosity of the extra-cellular space [35].
The calculated diffusion coefficients (DM) and cellular uptake (g) rates were not different for the two platinum compounds (Table 2), reflecting similar flux parameters for the two classes of platinum complex in a solid tissue.
Since diffusion of the FSH receptors, much as diffusion of the cytoplasmic estrogen receptors will be restricted by the cell boundaries, even if cellular diffusion was very fast, we will use D R = 10−7 mm s−1, the diffusion coefficient for unhindered membrane diffusion [ 27- 29, 108], for all other receptors.
It is noteworthy that in addition to kurtosis, non-Gaussian diffusion has also been investigated with two-exponential model (slow vs. fast diffusing compartments or intra- vs. extra-cellular compartments) [ 36, 37] and stretched exponential model (multiple compartments and thus continuous distribution of diffusion coefficients) [ 38].
To accurately deduce diffusion coefficients using RICS in live cells, one has to account for and subtract slow background motion (gross cellular motility) and movement of large visible vesicles or organelles that would give rise to fluctuations with an apparent diffusion of <0.002 μm/s.
Higher effective diffusion coefficients result in more advanced diffusion fronts.
The diffusion coefficients as derived in Sect.
while the dimensionless diffusion coefficients are d1 = d2 = 0.01.
For example, the diffusion coefficients have not been measured.
