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Acute lymphocytic and myeloid forms of leukemia arise as a consequence of an increased rate of mitosis (due to loss of cellular control over proliferation of transformed cells).
Once generated, PA can then be rapidly depleted from the plasma membrane by phosphatidic acid phosphatase or a variety of phospholipases, thus allowing tight cellular control over its abundance (Foster, 2013).
It has been widely assumed that it is the disorganized state of the callus phase which is responsible for the release of cellular control over mutagenesis, whether generated by exogenous (UV, stress etc).
We have recently introduced the concept of the "panjunctional SR", which states that Ca 2+ release and uptake at a family of specific nanojunctions connected by a continuous but variable SR lumen integrates cellular control over multiple functions.
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Malignant progression involves an accumulation of multiple alterations in cellular growth control over an extended period of time.
The in vitro assembling of cellular networks offering control over cell positions and connectivities by patterned culture substrates is a valuable tool for neuroscience research and other applications in cell biology.
These findings demonstrate the ability to exert a certain level of control over cellular responses with biomaterials and the potential to attain a desired cellular response such as, increased VEGF production or isotropic collagen deposition upon exposure to these materials in wound healing and tissue engineering applications.
However, mechanisms to exert specific control over cellular microenvironments remains a significant challenge.
This paradigm can be exploited to exert control over cellular behaviour.
Our work provides a genetic platform that can build programmable sensing-actuation devices enabling autonomous control over cellular behavior.
Protein kinases phosphorylating Ser/Thr/Tyr residues in several cellular proteins exert tight control over their biological functions.
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