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"They are prima donnas in the cellular context," he said.
Sweedler's approach thus trades cellular context and interaction for throughput.
Their relative importance for p62 stability is likely cellular context and stress type dependent.
Their action results in different outcomes depending on the developmental stage, tissue and/or cellular context.
ICWs are cell-based microplate assays for quantification of protein targets in their cellular context.
TNFα can induce either NF-κB-mediated survival or apoptosis depending on the cellular context [13].
Within the same cellular context, NR2F2 binds to the rat CYP7A1 promoter causing enhanced transcription [41].
Use of non-permeabilized cells allowed us to measure extracellular nucleotide hydrolysis in a cellular context.
In none of these studies was methyltransferase activity assessed in a normal cellular context.
Extracellular stimulus and the cellular context activate the phosphorylation of STAT3.
We speculate that these multi-targeted IRs interact with numerous other partners in a cellular context.
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