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The cellular consolidation process is a time-restricted process, with amnestic agents being effective only during a restricted time window (McGaugh, 2000).
Furthermore, Smith et al. (1991) have shown that administration of protein synthesis inhibitors (which block cellular consolidation cascades) during specific REM-sleep windows in rats prevents behavioral improvement following sleep, without requiring deprivation.
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A related phenomenon called synaptic tagging and capture (STC) has been proposed as a mechanism for cellular memory consolidation and to account for temporal association of memories.
Immediately following the ablation, a blood clot fills the space producing a fibrin and platelet laden substrate for a succession of cellular infiltrates (clot consolidation phase, days 1 3).
However, after eight weeks of infection, cellular infiltration and consolidation of the lungs was observed in naïve mice but was absent in lungs of rBCG immunized and control mice.
If proBDNF mediated cellular processes normally opposed consolidation, then reductions in proBDNF in the absence of changes in baseline mBDNF activity would be permissive for consolidation.
We assessed lung histopathology in mice immunized with rBCG-NS and observed less lung consolidation and cellular infiltration compared to non-immunized control mice.
During sleep, although energy expenditure and digestive processes decrease, many essential activities occur including cellular repair, toxin clearance, memory consolidation and information processing by the brain.
The Drosophila learning and memory circuitry has been well characterized and provides an excellent system in which to study cellular interactions between sleep and memory consolidation.
Telekom Malaysia will offer $1 billion to buy the shares it does not own in a rival mobile phone company, bidding to become the country's No. 1 cellular operator after a government call for consolidation.
In the nucleus, DISC1 interacts with the transcription factor Activating Transcription Factor 4 (ATF4), which is involved in the regulation of cellular stress responses, emotional behaviour and memory consolidation.
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