Sentence examples for cellular consequence of from inspiring English sources

A cellular consequence of lamin dysfunction in laminopathies is relaxation of heterochromatic DNA [1].

However, cells with a mutated topo IIα isoform and lacking topo IIβ did not arrest, suggesting that the cellular consequence of M2- or M3-APC expression depends on functional topoisomerase II.

The Markov model is then inserted into a human ventricular action potential model[22] and paced with twice threshold stimuli at a variety of pacing intervals to examine the cellular consequence of the mutation.

Our results highlight the loss of cohesion as an early cellular consequence of compromised splicing.

Alterations in metabolite profile can be considered the ultimate cellular consequence of environmental perturbations.

The final cellular consequence of particle action is an excess of osteoclast activity, which results in uncontrolled bone erosion.

The calcium-regulated transcription factor NFAT is emerging as a key regulator of neuronal development and plasticity but precise cellular consequences of NFAT function remain poorly understood.

Therefore, the rational application of channel inhibitors or activators is crucial to understanding the cellular consequences of mitochondrial channel inhibition or activation.

Here we investigated the molecular and cellular consequences of a naturally occurring FERMT1 mutation, c.299_301del resulting in a single amino acid deletion, p.R100del.

In this study, we generated LMNA-mutated and WRN-deficient human ESC lines with the same genetic background, making it possible to compare and contrast the cellular consequences of the genetic defects underlying HGPS and WS side-by-side.

On the contrary, D-chiroIns alone is unable to exert significant improvements in the ovarian cell functions, as its beneficial effects are mainly limited to the non-ovarian tissue in which it may significantly inhibit the negative cellular consequences of hyperinsulinemia.