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Calvi, L. M. & Link, D. C. Cellular complexity of the bone marrow hematopoietic stem cell niche.
Graduate School: Weill Cornell Medical College Graduate School of Medical Sciences, Memorial Sloan-Kettering Cancer Center, PhD under the guidance of Dr Eric Holland, "Understanding Cellular Complexity of Gliomas" The Yale Department of Neurosurgery is proud of our residents and what they've been able to accomplish! Louis Marotti, M.D., Ph.D.
Hence, to comprehend the outcome of cell biology research in clinical context, it is important that the cell culture based models should incorporate both the three dimensional (3D) organization and multi cellular complexity of an organ while allowing experimental interventions in a desirable manner.
Moreover, tumor cells growing in such conditions lack the architectural and cellular complexity of in vivo tumors, so it is impossible to recreate the interaction between the tumor and its host [4].
This process is probably central to the macromolecular and cellular complexity of higher eukaryotes.
However, due to the high cellular complexity of whole blood cells samples, whole gene expression patterns should be carefully analyzed and deciphered to allow returning to an integrative view of the molecular mechanisms altered during the pathophysiological process studied [25].
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One of the biggest challenges to the development of more organotypic in vitro models of the liver is the integration of the architectural and cellular complexities of the liver, while incorporating the important elements of the localized hemodynamics of the regional microenvironments.
We speculate that AS contributes to multi-cellular complexity of the fungi.
A related issue is the potential generation of models of greater cellular complexity to study the contribution of different cell types to AD pathogenesis, including astrocytes and microglia.
Moreover, electron microscopy reveals organelles, membranes, macromolecules, and thus aids in the understanding of cellular complexity and localization of molecules of interest in relation to other structures.
Lymphocyte activation was also evident by cytofluorimetric analysis because of an increase of cellular complexity (side scatter) of T cells cultured with bacteria, as compared to unstimulated control (data not shown).
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