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Due to its cellular complex and osteoid formation it is very difficult to understand the mechanism behind the progressiveness of osteosarcoma.
Using data from all groups, megalin and cubilin mean spectral counts were highly correlated, consistent with evidence that they form a cellular complex and are coexcreted in urine (Table 1).
The most common organism in localized pulmonary infection and disseminated infection was Mycobacteriam avium cellular complex, and M. abscessus predominated in skin and soft tissue infection and lymphadenitis (6, 8 ).
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We identified hundreds of genes whose downregulation led to elevated levels of H2AX phosphorylation (gammaH2AX) and revealed links to cellular complexes and to genes with unclassified functions.
Malignancy alters cellular complex lipid metabolism and membrane lipid composition and turnover.
In contrast, LEDGF/p75 has originally been identified in a cellular complex with multimeric IN32 and the protein is known to modulate the dynamic structure of HIV-1 IN by stabilizing subunit-subunit interactions63.
In my teens I caught the virus of vitalism from reading Arthur Koestler's The Ghost in the Machine – and was cured of it, ironically enough, by a creationist tract that extolled the wondrous complexity of cellular machinery: complex and wondrous enough, I realised, for life to need no other explanation.
Tat recruits the cellular pTEFb complex and interacts with several chromatin-modifying enzymes, including the histone acetyltransferases p300 and PCAF.
During viral infection, some viruses undergo degradation by cellular proteasome complex, and the cytosolic antigenic peptides are carried into the ER.
In order to assess the molecular weight of cellular complexes of endogenous Ii and MHCII molecules, we prepared lysates from Raji cells, separated the solubilized proteins on a sucrose density gradient, and detected DRα by western blotting.
Proteasomes are high molecular weight cellular complexes that degrade cytosolic and nuclear proteins into peptides in eukaryotic cells (Goldberg 2007).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com