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Cellular compartmentalization of RNAs is thought to influence their susceptibility to ribozyme cleavage.
Additional evidence for cell surface expression came from the confocal microscopy analysis of cellular compartmentalization of CD95 glycomutants.
Reduced 5-HT reuptake could also shift the cellular compartmentalization of 5-HT, increasing the extracellular concentration at the expense of intracellular stores by effectively trapping 5-HT outside cells.
In this work, we used gross dissections containing a mixed population of both neurons and glia to determine the cellular compartmentalization of NFκB; further studies to isolate the glial population in order to determine the glial cell SNCA load and level of NFκB activation in response to NAC may provide valuable insight into the mechanism of NAC-mediated neuroprotection in this model.
This cellular compartmentalization of PTEN was investigated in lung neuroendocrine tumors (lung NET).
The biosynthetic de novo pathway occurs in six steps, with cellular compartmentalization of specific steps in the cytosol or mitochondria.
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To further confirm that autophagosome formation was increased in Tzb-refractory cells, both the expression and the sub-cellular compartmentalization of LC3 in individual cells and in whole cell cultures were monitored by indirect immunofluorescence using an automated confocal-imaging approach.
In this light, it should be mentioned that the biggest challenge in the representation of the sub-cellular localization of eukaryotic metabolic pathways lies in acquiring the knowledge of sub-cellular compartmentalization of eukaryotic metabolic pathways.
Findings from this global approach hinted at differential sub-cellular compartmentalization of the edited and unedited transcripts, but did argue against the role of editing in nuclear retention – for transcripts prone to nuclear-specific editing, editing status did not correlate with their localization.
By contrast, the cytoplasmic isoform GPD1 (Cre12.g511150) was downregulated as part of a late-stage response, highlighting the importance of cellular compartmentalization to achieve modularity in metabolism.
Aguzzi, A. & Altmeyer, M. Phase separation: linking cellular compartmentalization to disease.
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