Sentence examples for cellular clock models from inspiring English sources

It is thus pertinent to ask why current cellular clock models almost universally have interlocked negative feedback loop (NFL) and positive feedback loop (PFL).

To this end, we studied the nuclear translocation of CRTC1; the resultant CREB-mediated Sik1 and Per1 induction; and the effect of SIK1 on the transcription of Per1 and on re-entrainment in both cellular clock models and the intact animal.

A hypothetical model of the internal cellular clock that takes into account these chromosomal changes during semiconservative replication is suggested by Berkovich [ 11].

This model proposes the existence of a cellular clock that interacts with a slowly progressing wave (wavefront) moving along the presomitic mesoderm (PSM) from anterior to posterior.

The intrinsic cellular clock consists of a transcription-translation feedback loop between the heterodimers Bmal/Clock and Per/Cry.

We also used genetic approaches to disrupt the intrinsic cellular clock and observed mild cognitive impairment in middle aged animals.

The faster a cellular clock runs, the more chances the cell's DNA has to mutate.

Neural precursor cells (NPCs) from the dentate gyrus express circadian clock genes and disruption of the cellular clock results in abnormal NPC division and maturation [40].

Pairs of homologous chromosomes control the cellular clock mechanism.

Uncorrelated lognormal relaxed clock models were used with estimated rates.

Their estimates using the relaxed clock model suggested more recent divergence events when compared with the global molecular clock models.