Fundamental cellular events central to the overall process of RIBE include chromosomal rearrangements, gene mutations, apoptosis, and genomic instability (Morgan and Sowa, 2007).
Aydemir research group is aimed at developing a greater understanding of how zinc and manganese function to regulate different cellular processes central to maintaining homeostasis, and thus health.
Other candidates belong to the categories of protein synthesis, cellular processes/detoxification, central intermediate metabolism, biosynthesis of amino acids and co-factors, energy and fatty acid metabolism and hypothetical proteins (Table 1).
S6K1 participates in numerous cellular processes central to promoting cell proliferation, cell growth and cell cycle progression [ 34, 35].
TRAPP is a modular protein complex that regulates entry into and exit from the Golgi, which is a cellular compartment central to multiple trafficking pathways.
Loss of YbeY resulted in up-regulation of several sRNAs (e.g. OxyS, DsrA, MicA, CyaR etc). in response to HU that in turn affect several cellular processes central to adaptation to oxidative stresses.
This contribution is an apparent reflection of the critical role of Sprouty in regulation of cellular processes central to the development, progression, and dissemination of malignant conditions, including cell proliferation, migration, invasion, transformation, and survival (Table 2).
It is not clear if the discrepancy is due to a different cellular environment (central nervous system versus other types of cells) or due to different stimuli (LPS/IFNγ instead of other stimuli).
The Notch signaling pathway is a central cellular signaling pathway involved in many essential cellular functions, and it is known to impact embryogenesis, central nervous development, cardiovascular development, and also angiogenesis (Andersson et al. 2011; Guruharsha et al. 2012).
Proteins that are part of the network show highly significant enrichment (all p-values <1e-7) in central cellular processes such as gene expression (GO 0010467), translation (GO 0006412), cellular localization (GO 0051641) and cell cycle (GO 0007049).
