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Finally, macrophages may indeed form part of a cellular bridge between robustly regenerative organisms such as zebrafish and the less regenerative mammals that could potentially be manipulated for mammalian regenerative therapies.
More recently, it has been shown that also dendritic cells acquire PrPSc in vitro, and transport directly into lymphoid tissues in vivo, suggesting that dendritic cells can serve as a cellular bridge between the gut lumen and the lymphoid compartment [ 16].
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I believe that habitats and humans share immune systems and mushrooms are cellular bridges between the two.
Cellular bridges, the longest direct connections between cells, facilitate transfer of cellular signals and components over hundreds of microns in vitro and in vivo.
Furthermore, the results can be used to evaluate the load-carrying capacity of existing composite cellular bridges since even a small increase in strength for live load can make the difference between closing a bridge and leaving it open.
Recently characterized cellular bridges - cytonemes and tunneling nanotubes (TNTs) - facilitate transfer of cellular signals and components, even pathogens, over hundreds of microns representing the longest direct connections between cells in vitro and in vivo [4] [9].
Such mapping can be viewed as a bridge between cellular level and organ systems physiology, e.g., by facilitating the development of advanced theoretical concepts of arrhythmia.
In a sense, these maps are the missing bridge between cellular views made possible by looking through a microscope and molecular views made possible by sequencing of the genome, Iyer says.
These facts have built the first bridge between cellular and humoral autoimmunity in a major rheumatic disease, supporting a pathogenetic role for an abnormal metabolism of citrulline in the development of RA [ 13, 14].
Our interest in NK cells stems from their ability to directly lyse infected and tumor cells and to mediate antibody-dependent cellular cytotoxicity, acting as a bridge between innate and adaptive immune responses.
We have analysed the factors that shaped Fur regulatory functions in different bacteria in order to create a bridge between origin and cellular role.
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