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While, the presence of intrinsically unstructured regions, which is attributed by the occurrence of genes containing repeat sequences, increased protein stability and the functional constraint to perform the transcription regulatory jobs, enriches the network connectivity to be involved in important cellular assignments and increase the stability in transcriptional level.
Our findings imply that, the affluence of disordered regions elevating the network attachment to be involved in important cellular assignments and the stability in transcriptional level are acting as the prevailing forces behind the high expressivity of the human genes configuring processed pseudogenes.
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For example, Chen et al. [32] put forward an image processing method based on discrete neural models, which were implemented on circuits; Wang et al. [33, 34] proposed the discrete Hopfield neural models for Max-cut problems and cellular channel assignments; and Yashtini et al. [35] gave the discrete model for nonlinear convex programming.
Protein sub-cellular localization assignments are retrieved via webservices from SUBA [42].
While in the unrefined transcript list, about 65% (217/341) of gene products with a cellular component assignment are related to "chloroplast" and "mitochondrion" (data not shown).
For cellular components, the assignments were mostly nucleus (15,104) and plasma membrane (13,613; Figure 3).
For cellular components, those assignments were mostly given to cell (37,809) and cell part (37,803).
Among the 18 subcategories of cellular components, those assignments were mostly given to cell part and organelle.
We used multicolor flow cytometry analysis of the same tumors to confirm our assignments of cellular lineages and validate our predictions of expressed proteins.
For the cellular component class the assignments were mostly given to cell and organelle (54,82% and 29,35% respectively; Additional file 1: Figure S1a).
Finally, for the cellular component class the assignments were mainly given to the plastid (36%), mitochondrion (33%), and cytoplasmic membrane-bound vesicle (29%) components.
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