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Downstream, this effect results in the upregulation of hypoxia-regulated genes, leading to cellular and morphologic changes characteristic of PH.
Renal ischemia reperfusion causes cellular and morphologic damage primarily in cells in the outer medullary region (Heyman et al. 1988, 2010; Lieberthal and Nigam 1998).
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Heat shock proteins (Hsps) are involved in cellular defense and morphologic changes of organisms at developmental stages (Feder and Hofmann, 1999; Gunter and Degnan, 2007).
Importantly, cell death was not observed before 2 hr treatment with TPT, as shown by lack of caspase-3/7 activation, PARP cleavage, and cellular morphologic changes (data not shown).
Blood and lymphoid tissues were evaluated for morphologic, cellular, and molecular responses.Irradiated animals developed symptoms of acute hematopoietic syndrome, and reductions in thymus weight, thymopoiesis, and bone marrow cellularity.
Optical imaging is ideally suited to detecting cancer-related alterations because it can detect biochemical and morphologic alterations with sub-cellular resolution throughout the entire epithelial thickness.
Here we combine cellular morphologic and molecular genetic analyses to address the hypothesis that EOC may arise in ovarian cystic inclusions.
Furthermore, cell death also occurred in a dose-dependent fashion in the cells treated with TPT or TBT, as supported by cellular morphologic changes and PARP cleavage into p85 and p65 fragments.
The malignant transformation of precancerous colorectal lesions involves progressive alterations at both the molecular and morphologic levels, the latter consisting of increases in size and in the degree of cellular atypia.
FF stabilizes cellular morphology and tissue architecture, and can be used to study the distinct morphologic and genetic signatures of different cell types.
On histology, both are characterized by an expansion of the cellular and acellular stromal tissue as well as morphologic changes within myocytes, among other features.
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