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Detailed analysis of the small number of genes mutated in F32-ART5 parasises is needed to gain insights about the cellular alterations underlying multidrug tolerance.
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Whether serving as drug carriers or beyond, a wise design of the nanoparticulate systems to overcome the cellular and intracellular alterations underlying the resistance is imperative.
Recent evidence suggests that peripheral clock gene expression is subject to local metabolic (including aging) and mechanical stimuli, which also lead to epigenetic alterations underlying cellular dysfunction.
The Cancer Genome Atlas (TCGA) has catalyzed systematic characterization of diverse genomic alterations underlying human cancers.
Differences in the molecular alterations underlying the development of uterine sarcomas and adenocarcinomas are significant.
However, somatic alterations underlying these phenomena remain unexplained.
The pathophysiological alterations underlying SAE are incompletely understood.
The biological alterations underlying this pattern remain unknown.
There are also parallels between the neurochemical alterations underlying the lead-induced cognitive impairments and the neurochemical alterations believed to underlie ADHD (Brennan and Arnsten 2008).
Whole genome sequencing (WGS) has allowed an unprecedented insight into the alterations underlying cancer.
These indices thus provide insight into the architectural alterations underlying the neurochemical effects of ETS.
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