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Lesions were classified as foci of cellular alteration smaller than one liver lobule (altered hepatic foci; AHF), foci of cellular alteration larger than one liver lobule (large foci of cellular alteration; LFCA), adenomas (ADs), or carcinomas (CAs).
Thus, one of the main aspects of PM will be to identify biomarkers able to characterise a cellular alteration leading to subclinical or manifest disease status as well as its specific reaction to various therapeutic attempts [9].
Despite a softer consistency of the cortices dissected from jaundiced jj rats, vascular morphology was similar to Jj rats and no cellular alteration (granulations, bubbles, etc).
This complex cellular alteration was dependent on SPION chemical composition and its concentration in solution.
Preneoplastic lesions include principally basophilic foci of cellular alteration and hepatocellular adenoma.
Nine months postexposure, KC juveniles exhibited significantly more hepatic foci of cellular alteration and only KC juveniles developed hepatocellular carcinomas.
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This leads to subsequent cellular alterations that increase the risk of cells altered by pre-cancerous genetic changes [ 3, 23- 28].
Thus, the cellular alterations which occur at sub-MICs of diclofenac and alter antibiotic susceptibility (i.e. 32-64 μg/ml) are mechanistically-distinct from alterations associated with mutations leading to the DcRS phenotype selected from 1× MIC (500 μg/ml).
This study describes both molecular and cellular alterations in menisci during the early stages of OA development.
Histologically also no morphological and cellular alterations were observed in the placentae of pregnant-infected treated mice.
Sublethal ischemia, however, leads to cellular alterations, termed "hypoxic priming," of second messengers, such as cellular ionized calcium (Ca2+), cyclic cAMP, phosphatidic acids, and ROS [197 200].
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