The hypoxia-inducible transcription factors (HIFs) directly and indirectly mediate cellular adaptation to reduced oxygen tensions.
Patten, D. A. et al. OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand.
Kaidi, A., Williams, A. C. & Paraskeva, C. Interaction between β-catenin and HIF-1 promotes cellular adaptation to hypoxia.
Bacterial cold shock proteins (CSPs) are involved in cellular adaptation to cold stress.
The yeast HOG (High Osmolarity Glycerol) response pathway mediates cellular adaptation to hyperosmotic stress.
Kim, J. W., Tchernyshyov, I., Semenza, G. L. & Dang, C. V. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia.
Gui, D. Y., Lewis, C. A. & Vander Heiden, M. G. Allosteric regulation of PKM2 allows cellular adaptation to different physiological states.
PDK-1 expression is responsible for the reduction in ROS generation under hypoxic conditions23, 24 and the metabolic switch for cellular adaptation to hypoxia12, 13. mRNA expression of PDK-1 was decreased significantly by treatment with the siRNA (Fig. 5b).
The orchestrated regulation of the autophagy lysosomal system by TFEB/ZKSCAN3 highlight the importance of this pathway in cellular adaptation to environmental cues, which might be altered in pathological settings such as cancer.
We integrated scRNA-seq analysis of PND1 mouse lung with developmental RNA profiles obtained from whole lung tissue to begin to understand the complexity of cellular adaptation of the lung to air breathing at birth.
The metabolic changes characteristic of the chaperone deficient mutants, not observed in neither CCCP treatment, nor in the COA3-null mutant, may have a role to mitigate the proteotoxicity by aiding cellular adaptation to requirements of coping with stress.
