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If that damage is deemed too extensive by other cellular actors that interact with p53, it triggers p53 to launch the call for the cell to commit suicide.
In normal wound healing, platelets establish regulatory crosstalks between soluble and cellular actors of tissue repair that concur to the various phases of inflammation and reestablishment of tissue homoeostasis [50, 83, 104, 105].
Consequently, the same cellular actors are key elements defending the host against infection while simultaneously contributing to deleterious events.
Extensive study of these models has defined important cellular actors of cell death including oxidative stress, mitochondrial dysfunction, excitotoxicity, neuroinflammation and nitric oxide which is presumably critical of the nigral degeneration [ 13, 14].
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According to a study reported here on Saturday at the annual meeting of the American Association for the Advancement of Science (which publishes ScienceNOW), immune cells from a handful of people--including two men infected with HIV who later cleared the virus--blocked HIV after it entered the cells, suggesting that these people carry an unknown cellular actor that protects them.
In sepsis, many cellular and soluble actors concur to activate the endothelium.
Proteins are one of the major actors in cellular processes and perform many different functions, which are required for the survival of a cell and an organism.
As mediators of cellular communication, MPs are actors and possible mediators in the interplay between throm-bosis and inflammation, a process previously described for vascular injury in inflammatory diseases [ 5].
Concurrently, new actors in the cellular regulation plot are being investigated.
Analysis in different mutant backgrounds revealed that AdcA phosphorylation involves pathways other than the DokA and cGMP-dependent osmostress pathways, respectively known to regulate PKA and STATc, key actors in the cellular response to conditions of hyperosmolarity.
Recent studies indicate that circadian clock proteins may be involved in DNA repair and in regulating accumulation of cellular ROS, thus making them plausible actors in the aging processes [ 48].
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CEO of Professional Science Editing for Scientists @ prosciediting.com