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The discovery that cells taken from just about any part of the human body can be induced to revert to stem cells with the ability to re-differentiate into any other cell type raised hopes, until it was subsequently found that these so-called pluripotent stem cells harbour genetic defects and can cause tumours when transplanted.
But the first step is to single out those cells with the ability to persist for a long time.
The proposal would allow these researchers to make T cells with the ability to attack three inherited types of cancer.
To date, whether there are undifferentiated multipotent stem cells with the ability to self-renew indefinitely in lung is controversial.
Myeloid-derived-suppressor cells (MDSCs) have been identified as a population of immature myeloid cells with the ability to suppress T cell activation, contributing to cancer proliferation [51].
Metabolic engineering is the science of rewiring the metabolism of cells to enhance production of native metabolites or to endow cells with the ability to produce new products.
Molecular reciprocity between the Ras/MEK/ERK and PI3K/Akt/mTOR pathways provides cancer cells with the ability to evade treatment when targeting only one pathway with monotherapy.
A decrease in intracellular GSH levels, rather than an increase, was observed in GGT-transfected cells; moreover, in cysteine-deficient conditions, the expression of GGT did not provide transfected cells with the ability of utilising extracellular GSH.
Studies that have used massively parallel sequencing have shed light on the rich functional landscape of mutations that endow tumour cells with the ability to evade T-cell-mediated immunosurveillance.
This adaptation endows the cells with the ability to survive more severe stresses.
Consequently, in situ analysis of cytokine expression by T cells probably represents an underestimation of the percentage T cells with the ability to produce a cytokine of interest.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com