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While many microbial phenotypes appear to be the product of cooperative interactions among cells, understanding the biological function of these traits requires that we understand how they contribute to microbial fitness.
Casellas, R. et al. Mutations, kataegis and translocations in B cells: understanding AID promiscuous activity.Nat.Nat
As DNA damage can arrest proliferation, and, in the case of myeloid leukemia, induce differentiation of cancer cells, understanding the mechanisms that regulate the replication stress response is paramount.
She specifically focuses on gamma delta T cells, understanding their role in the immune response process and why they proliferate during infection.
Since monomeric and multimeric receptors coexist in cells, understanding the functional role of just the TSHR multimers is difficult.
Because autophagy is related to fate determination in cancer cells, understanding the relationship between autophagy and apoptosis is critical for the development of cancer therapies.
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While transcription is a time-evolving process inside a cell, understanding how its regulation participates in the decoding of spatial information in a developmental system requires a concurrent consideration of time and space on a much larger scale.
This perspective emphasizes the critical value of dynamic analysis of molecular expression in single cells for understanding cell fate decisions [ 14, 15].
Cell biology Understanding cell behavior often requires isolation of cell subpopulations to reduce heterogeneity in the studied sample, such as stem cells, CTCs, cancer stem cells, and white blood cell subpopulations.
For stem cell characterization, understanding single cell level functional genomics has become increasingly important [1], [2], [3], [4], [5], [6], [7], [8].
Regulatory Genomics and Epigenomics aim to understand the way gene expression is controlled in cells by understanding the sequence elements and organization that govern this expression.
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