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Palmer, D. C. et al. Vaccine-stimulated, adoptively transferred CD8+ T cells traffic indiscriminately and ubiquitously while mediating specific tumor destruction.
These findings suggest that the antigen-presenting capacity can be defined before cells traffic into the periphery and is not entirely reliant on cues experienced at the tumor site.
Recent work supports their use in multiple myeloma by showing that ex vivo antigen-specific expanded T cells traffic to and persist in bone marrow, are well tolerated, and produce promising response rates when infused after stem cell transplantation.
These data identify a novel class of ligands for SREC-I and provide insight into the mechanisms by which APCs and potentially endothelial cells traffic chaperone/antigen complexes.
Breast cancer cells traffic to and from the peripheral blood within specific vascular niches, and this migration can be therapeutically targeted.
So, there are additional users around the small cells (traffic hotspot) and an additional uniform user distribution for the macro cell area.
Similar(33)
Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues.
Dynamic imaging of allogeneic mesenchymal stem cells trafficking to myocardial infarction.
We found that CD3+ cells, but not CD3- cells, trafficked to lymph nodes (Fig. 6B).
Cells trafficked from the blood to peripheral lymphoid tissues within 12 hours of transfer.
Chemokines play important role in cells trafficking during immune responses.
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