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As such, the ability for rhBMP2_108 to speed up the rate and number of progenitor cells to defects sites is crucial for bone repair.
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Indeed, HIV infection leads, in addition to the progressive depletion and dysfunction of CD4+ T cells, to extensive defects in the humoral arm of the immune system [ 14].
A recent report observed that reduced sLex expression on lung epithelial cells contributes to defects in airway wound repair [31].
However, depletion of ATRX in mammalian cells leads to defects in chromosome cohesion and mitotic progression [12].
Both Trim24 and Gfi1 have known effects on p53 function in cells, leading to defects in growth and development.
These data indicate that cells respond to defects in ribosome synthesis by changing the level of expression of a limited subset of genes involved in critical cellular processes.
Transient depletion of HP1α, but not HP1β or γ, in tumoural and primary human cells leads to defects in chromosome segregation.
The most common molecule paired with HA scaffolds are growth factors, which recently have been shown to be able to recruit endogenous stem cells to a defect site and allow for de novo tissue regeneration [41].
The local adherent technique we describe here made it possible to adhere the cells to the defect site more effectively than an intra-articular injection technique.
Mice deficient in E2F1, for example, have excess T-cells owing to defects in thymocyte apoptosis, and E2F1 has been shown to activate the expression of Apaf-1.
In addition to the cell lysis phenotype of GroE-depleted E. coli, it has been reported that cells with impaired GroE exhibit filamentous cell morphology owing to defects in cell division [ 27].
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