By mapping the m6A methylome in embryonic stem cells, thousands of mRNAs and lncRNAs including transcripts encoding core pluripotency transcription factors, were found to show conserved m6A m6Aification57.
In human cells, thousands of origins of replication are coordinately activated during S phase, and the velocity of replication forks is adjusted to fully replicate DNA in pace with the cell cycle1.
In reality, the scientists grew thin sheets of bovine muscle cells — thousands of sheets, each no wider than a strand of hair — which they essentially fused together with a kind of meat glue.
The Wannsee Protocol laying out the plan and execution of the Holocaust was also finalised in offices on the site, while in nearby prison cells thousands of people – among them Jews, Roma and Nazi opponents – were held and often tortured before being sent to concentration camps.
In living cells, thousands of biochemical reactions are implemented in a coordinated fashion to produce an enormous number of metabolites.
Similarly, when comparing cancer cells to normal cells, thousands of genes are often differentially expressed, rendering discrimination of the most salient, primary changes from correlated, downstream changes difficult.
